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Programme
NB: Participants who have been selected to talk should not bring a poster.
Sunday, 18 August
[Edge Conference Centre]
| 14:00-18:00 |
Delegate Arrival and Registration & afternoon refreshments |
| 18:00-19:00 |
Self-service evening meal (for All-Inclusive Residential Delegates and Accompanying Persons) |
| 20:00-21:00 |
Drinks Reception (For all Registered Delegates) |
| 21:00 |
Bar Open in Edge Conference Centre |
Monday, 19 August
| 8:30-10:30 |
Welcome and Introduction Graham Pockley (Nottingham) [10 min] Historical Context Chairs: Robert Tanguay (Québec) & Graham Pockley (Nottingham) Robert Tanguay (Québec) [55 min] Ferruccio Ritossa and a history of stress protein research Irun Cohen (Rehovot) [55 min] Modulating autoimmune disease with HSP-based therapy: the example of type 1 diabetes |
| 10:30-11:00 |
Morning Tea and Coffee & Poster Viewing |
| 11:00-12:35 |
Tissières Award Session Chairs: Lawrence Hightower (Storrs) & Graham Pockley (Nottingham) Lawrence Hightower (Storrs) [5 min] Introduction and context of the award María Bausero (Montevideo) [30 min] In search for the proper carrier Justin Benesch (Oxford) [30 min] Weighing the evidence for small heat-shock protein chaperone mechanism Thomas Prince (Bethesda) [30 min] HSP90-client protein interactions: kinases and transcription factors |
| 12:35-14:00 |
Hot Buffet Lunch & Poster Viewing CSSI Council and Cell Stress & Chaperones Editorial Board Meeting |
| 14:00-16:00 |
Lawrence Hightower Session Chairs: Antonio De Maio (San Diego) & Graham Pockley (Nottingham) Antonio De Maio (San Diego) [10 min] Introduction Michael Tytell (Winston-Salem) [10 min] Outside the box Robert Tanguay (Québec) [25 min] Larry’s story R. William Currie (Halifax) [25 min] Friends from a long time George Perdrizet (Warwick) [25 min] The UCONN stress response: trials and tribulations of collaborative medical science Emily Noonan (Bethesda) [15 min] Professor Hightower, a mentor Graham Pockley (Nottingham) [10 min] Concluding remarks |
| 16:00-16:30 |
Afternoon Tea and Coffee & Poster Viewing |
| 16:30-18:20 |
Heat Shock Proteins in Cancer Therapeutics Chairs: Graham Pockley (Nottingham) & María Bausero (Montevideo) Weiwen Ying (Lexington) [30 min] Development update of Ganetespib, a Hsp90 inhibitor in multiple advanced clinical trials Rahul Samant (London) [15 min] The E3 ubiquitin ligase CUL5 is required for multiple aspects of the HSP90 inhibition response in human colon cancer cells Carly Smith (Chester) [15 min] Differential response to HSPC1 inhibitors by chronic lymphocytic leukaemia cells Mathias Gehrmann (Munich) [15 min] Application of granzyme B for the treatment of radiation-resistant Hsp70 membrane-positive tumors Gemma Foulds (Munich & Nottingham) [15 min] Tracking the selective internalisation of granzyme B into membrane Hsp70 positive cancer cells using confocal microscopy María Bausero (Montevideo) [20 min] Supraparamagnetic iron oxide nanoparticles (SPIONs) as a novel siRNA-Hsp27 delivery system for cancer treatment |
| 18:30 |
Coaches leave the Edge Conference Centre for Millennium Gallery Reception and Buffet - kindly sponsored by the Cell Stress Society International |
| 22:00 |
Return and Edge Conference Centre Bar Open |
Tuesday, 20 August
| 8:30-8:45 |
Announcement and Presentation of Alfred Tissières Award Winner Lawrence Hightower (Storrs) & Graham Pockley (Nottingham) |
| 8:45-10:30 |
Network and Bioinformatic Approaches for Studying the Stress Response Chairs: Graham Ball (Nottingham) & Tamás Korcsmáros (Budapest) Tamás Korcsmáros (Budapest) [45 min] Integrated signaling and regulatory networks to facilitate systems-level understanding of stress responses Graham Ball (Nottingham) [45 min] A systems biology view of heat shock proteins within breast cancer Lorraine Mutsvunguma (Grahamstown) [15 min] Bioinformatic analysis of DNAJC3, a type 3 DNAJ protein |
| 10:30-11:00 |
Morning Tea and Coffee & Poster Viewing |
| 11:00-13:00 |
Parallel Sessions Heat Shock Factors I Chair: Valérie Mezger (Paris) & Thomas Prince (Bethesda) Thomas Prince (Bethesda) [30 min] Hsp90-client interaction is modulated by charge linker phosphorylation Reiko Akagi (Hiroshima) [20 min] Glutamine protects intestinal barrier function in Caco-2 from various stresses by modulating Hsp’s expression Thomas Czerny (Vienna) [20 min] HSF1 mediated stress response by heavy metals Valérie Mezger (Paris) [30 min] Crosstalk between stress-responsive pathways governed by HSFs, and epigenetic regulations in the normal and diseased developing brain Dhruv Lavania (New Delhi) [20 min] Regulation of OsClpB-cyt/ Hsp100 promoter by OsHsfA2c Heat Shock Induced Membrane Remodelling Chairs: László Vígh (Szeged) & Imre Gombos (Szeged) Zsolt Balogi (Linz) [10 min] Introduction Kyohei Umebayashi (Geneva) [30 min] Stress response elicited by lipid sensing Zsolt Balogi (Linz) [30 min] Heat shock proteins regulating membrane function Imre Gombos (Szeged) [30 min] Membranes and lipids in the heat stress management Tim Crul (Szeged) [20 min] Plasma membrane modulations as novel tools to target the inducibility of specific heat shock proteins |
| 13:00-14:00 |
Hot Buffet Lunch & Poster Viewing |
| 14:00-16:00 |
Parallel Sessions Heat Shock Factors II Chairs: Lea Sistonen (Turku) & Matthias Mayer (Heidelberg) Anniina Vihervaara (Turku) [20 min] Heat shock factors HSF1 and HSF2 as transcriptional regulators of stress response in cycling and mitotic cells Elizabeth Christians (Salt Lake City) [20 min] Hsf1 and Hsf2 splicing isoforms: a not yet fully understood layer of diversity in HSF family Matthias Mayer (Heidelberg) [20 min] Conformational dynamics of human heat shock factor 1 Sachiye Inouye (Hiroshima) [20 min] Modulation of heme-oxygenase gene expression by heat shock factor 1 Ayesha Murshid (Boston) [20 min] Role of HSF1 and FoxO3 in proteotoxic stress induced macroautophagy Giovanni Li Volti (Catania) [20 min] Proteomics identify novel chaperones and antioxidant proteins contributing to coffee beneficial effects in steatohepatitis Small Heat Shock Proteins Chair: Robert Tanguay (Québec) Justin Benesch (Oxford) [20 min] Heterogeneity, dynamics and allostery of the small heat-shock protein αB-crystallin Stephen Weeks (Leuven) [15 min] Structural and biochemical studies of human HSPB6 - a model sHsp for characterizing the active chaperone state Pierre Goloubinoff (Lausanne) [20 min] Hsp70s and Hsp60s are ATP-fuelled polypeptide unfoldases: What about small HSPs? Wilbert Boelens (Nijmegen) [15 min] Pseudophosphorylated αB-crystallin is a nuclear chaperone imported into the nucleus with help of the SMN complex Serena Carra (Modena) [20 min] Implications of HSPBs and BAG3 in protein aggregate neuro/muscular diseases Stéphanie Finet (Paris) [15 min] Structural and functional properties of small heat shock proteins involved in myopathies and cataracts Leanna Bloxam (Liverpool) [15 min] Genome-wide analysis of small heat shock proteins involved in yeast ageing |
| 16:00-16:30 |
Afternoon Tea and Coffee & Poster Viewing |
| 16:30-18:30 |
Parallel Sessions Heat Shock Proteins in Infectious Disease Chairs: Addmore Shonhai (KwaDlangezwa) & Gregory Blatch (Melbourne) Addmore Shonhai (KwaDlangezwa) [15 min] Heat shock proteins in infectious diseases - Introduction Abhinav Joshi (Varanasi) [30 min] Analysing the Hsp90–actin interactome in filarial parasites – a powerful, broadly effective novel drug target for parasitic diseases? Utpal Tatu (Bangalore) [30 min] Heat shock protein 90 as a drug target against neglected diseases Adele Burger (Grahamstown) [15 min] Exploring the chaperone functions of a novel heat shock protein, Hsp70.c, from Trypanosoma brucei Xolani Makhoba (Kwazulu) [15 min] Exploring the effect of various chaperone combinations towards facilitating the production of recombinant Plasmodium falciparum AdometDC protein in E. coli Gregory Blatch (Melbourne) [15 min] Heat shock proteins in infectious diseases – Summing Up Plant Heat Shock Proteins and Plant-Based Therapies Chairs: Alexzander Asea (Atlanta) & Anil Grover (New Delhi) Anil Grover (New Delhi) [30 min] All three rice ClpB/Hsp100 proteins (ClpB-cytoplasmic, ClpB-plastidial and ClpB-mitochondrial) can complement the seed basal thermotolerance phenotype of Arabidopsis hot1-3 mutant lacking ClpB-cytoplasmic protein Ratnesh Mishra (New Delhi) [15 min] Genetic regulation of rice and Arabidopsis ClpB-cytoplasmic/Hsp100 genes Yafit Kushner (Tel Aviv) [15 min] The Zea mays chloroplast chaperonin system: toward a new strategy for engineering more efficient Rubiscoe Alexzander Asea (Atlanta) [30 min] Use of adaptogens in the design of central nervous system (CNS) related disorders Alexander Panossian (Vallberga) [15 min] Evaluation of molecular chaperons Hsp72 and neuropeptide Y as characteristic markers of adaptogenic activity of plant extracts Evren Önay Uçar (Istanbul) [15 min] Can stress proteins expression be suppressed by mistletoe extract? |
| 18:30 |
Coaches leave the Edge Conference Centre for Kelham Island Museum Reception and Buffet - kindly sponsored by StressMarq Biosciences Inc. |
| 22:00 |
Return and Edge Conference Centre Bar Open |
Wednesday, 21 August
| 8:30-10:30 |
Early Career Researcher Open Session Chairs: Graham Pockley (Nottingham) & Mathias Gehrmann (München) Stefan Stangl (Munich) [20 min] Novel antibody for in vivo imaging of membrane Hsp70 positive tumors and metastases Luca Vanella (Catania) [20 min] Adipose tissue-mesenchymal stem cells transplantation and oxidative stress in rats with acetaminophen liver injury Peter Bell (Newcastle upon Tyne) [15 min] ARMET/MANF and CRELD2 are components of an ER stress response provoked by inappropriate formation of disulphide bonds: implications for genetic skeletal diseases Xiaosheng He (Wuhan) [15 min] The relationship of urinary metals with plasma IL-6 and HSP70 in coke oven workers Sheah Lee (Chester) [15 min] HSPA1A and HSPB1 have a role in mediating chemoresistance in colorectal cancer cells Adam Lightfoot (Liverpool) [15 min] Overexpression of HSP10 in skeletal muscle protects against endotoxic shock-induced loss of muscle force generation Aaron Petersen (Melbourne) [20 min] Skeletal muscle heat shock protein response to lower limb unloading and reloading in humans |
| 10:30-11:00 |
Morning Tea and Coffee & Poster Viewing |
| 11:00-13:00 |
Parallel Sessions Heat Shock Proteins in Cancer Chairs: Michael Sherman (Boston) & Robert Binder (Pittsburgh) Robert Binder (Pittsburgh) [30 min] Extracellular heat shock proteins in cancer Michael Sherman (Boston) [30 min] Intracellular heat shock proteins in cancer Toshihiko Torigoe (Sapporo) [15 min] Unique characteristics of stress tolerance common to cancer stem cells and spermatogenous cells Adrienne Edkins (Grahamstown) [15 min] The Hsp90 chaperone complex regulates multiple processes during cell migration Teresa Colvin (Boston) [15 min] The role of heat shock protein HSP72 and co-chaperone BAG3 in cancer signaling Lara Contu (Grahamstown) [15 min] The role of Hop in pseudopodia formation in Hs578T breast cancer cells Stress Granules Chairs: Imed Gallouzi (Montreal) & Rachid Mazroui (Québec) Imed Gallouzi (Montreal) [30 min] The role of stress granules and processing bodies in senescence and a general introduction to the session Rachid Mazroui (Québec) [30 min] Inactivation of the mTORC1-eIF4E pathway alters stress granules formation Anaïs Aulas (Montreal) [20 min] The ALS-linked RNA-binding protein TDP-43 regulates stress granule dynamics and function Emily Towers (London) [20 min] Characterising the cochlear response to stress: Identifying a role for stress granules in sensory hair cells Fernando Valiente-Echeverria (Montreal) [20 min] eEF2 and G3BP-1 interact with HIV-1 Gag to mediate a block to stress granule assembly |
| 13:00-14:00 |
Hot Buffet Lunch & Poster Viewing |
| 14:00-16:00 |
Parallel Sessions Heat Shock Proteins and Immuno Regulation Chairs: Willem van Eden (Utrecht) & Christina Bonorino (Porto Alegre) Thiago Borges (Porto Alegre) [30 min] Innate immunosuppressive mechanisms of Hsp70 in transplants Femke Broere (Utrecht) [30 min] Heat shock proteins as dampers of inflammation Martijn van Herwijnen (Utrecht) [20 min] Hsp70-specific regulatory T cells are potent suppressors of autoimmune arthritis Kamal Moudgil (Baltimore) [20 min] HSP65-induced regulation of autoimmune arthritis Pavel Stocki (Newcastle upon Tyne) [20 min] In vitro assessment of the anti-inflammatory properties of HSP70 Spatio-Temporal Organization of Protein Folding and Aggregation in Living Cells Chair: Daniel Kaganovich (Jerusalem) Daniel Kaganovich (Jerusalem) [30 min] Overview: Spatio-temporal organization of protein folding and aggregation in living cells Elisabeth Nueske (Dresden) [30 min] Protein self-assembly in response to stress Anat Ben-Zvi (Beersheba) [30 min] Visualizing chaperones at work on the C. elegans sarcomere Nevena Hristozova (Brussels) [15 min] Intrinsically disordered LEA proteins as molecular chaperones Stanley Makumire (Empangeni) [15 min] Assessment of the effects of citrate capped gold nanoparticles on the structural integrity of proteins and DNA |
| 16:00-16:30 |
Afternoon Tea and Coffee & Poster Viewing |
| 16:30-17:00 |
Plenary Lecture Subhash Lakhotia (Varanasi) Long non-coding RNAs and the cell stress response |
| 17:15-19:15 |
Parallel Sessions Heat Shock Proteins in Cancer Radiotherapy Chairs: Gabriele Multhoff (Munich) & Franz Rödel (Frankfurt) Gabriele Multhoff (Munich) & Franz Rödel (Frankfurt) [15 min] Introduction Mehdi Mollapour (Bethesda) [15 min] Hsp90 N-domain SUMOylation regulates chaperone function Christine Bayer (Munich) [15 min] Soluble HSP70 as a tumor-specific biomarker for tumor detection and monitoring the outcome of radiation therapy Stephanie Ertl (Munich) [15 min] Development of a novel ELISA for detecting inducible Hsp70 in serum Anna Habryka (Gliwice) [15 min] HSPs expression under hypoxia and oxidative stress in normal keratinocytes and skin squamous cell carcinoma (A431) Paul Rühle (Erlangen) [15 min] Role of stress proteins and the immune system in radio-immunotherapy of cancer Daniela Schilling (Munich) [15 min] The small molecule Hsp70 inhibitor NZ28 increases the radiosensitivity of tumor cells Franz Rödel (Frankfurt) [15 min] Targeting and radiosensitization of glioblastoma cells by cmHsp70.1-antibody coated and Survivin miRNA plasmid loaded nanoparticles Chaperones in Cardiometabolic Diseases Chairs: Kylie Kavanagh (Winston-Salem) & Philip Hooper (Aurora) Georg Wick (Innsbruck) [15 min] A Darwinian-evolutionary concept for HSP-induced disease Philip Hooper (Aurora) [15 min] The near seminal event in the pathogenesis of type 2 diabetes: loss of the cellular stress response Zsigmond M. Jenei (Budapest) [15 min] Extracellular HSP70 (HSPA1A) level as a marker of cell damage is a prognostic marker of mortality in patients with heart failure Kylie Kavanagh (Winston-Salem) [15 min] Ageing-related insulin resistance is driven by skeletal muscle HSP70 Lingjia Qian (Beijing) [15 min] Role of HIP, HSP70 interacting protein, in stress induced cardiomyocyte damage and its molecular mechanism Tatsuya Kondo (Kumamoto) [15 min] Heat shock response activation using heat treatment with mild electrical stimulation reduces visceral adiposity and improves insulin resistance and inflammation in male subjects with type 2 diabetes Laura Anspach (Mainz) [15 min] The role of chaperone BiP in angiogenesis and inflammation Hirofumi Kai (Kumamoto) [15 min] Beneficial effects and their molecular mechanisms of specific pulse width mild electrical stress and physical medicine |
| 19:30-24:00 |
BBQ & Poster Viewing (Edge Conference Centre) |
Thursday, 22 August
| 8:30-10:30 |
Parallel Sessions Biological Effects of Extracellular Heat Shock Proteins Chairs: Antonio De Maio (San Diego) & Najmeh Moein Vaziri (Sheffield) Antonio De Maio (San Diego) [5 min] Introduction and the context of the session Wei Li (Los Angeles) [30 min] Extracellular Hsp90a (eHsp90a) signals through the sub-domain II and NPVY motif of LRP-1 receptor to Akt1 and Akt2: the essential mechanism for promoting skin cell migration in vitro and wound healing in mice Najmeh Moein Vaziri (Sheffield) [20 min] Exogenous HSPA8 prolongs sperm survival by enhancing membrane fluidity in a cholesterol-dependent manner Christina Bonorino (Porto Alegre) [20 min] Extracellular Hsp70 polarizes macrophages to the M2 phenotype Stefan Tukaj (Lübeck) [15 min] Aberrant expression and secretion of heat shock protein 90 in patients with bullous pemphigoid Fabiana Geraci (Palermo) [15 min] Hsp70 levels regulate MMP2 expression in mesoangioblast stem cells Morgan Hunter (Grahamstown) [15 min] Heat shock protein 90 (Hsp90) binds directly to the extracellular matrix protein fibronectin (FN) Neural Stress Responses I: Regulation of the Neuronal Stress Response Chairs: Ian Brown (Toronto) & Michael Cheetham (London) Ian Brown (Toronto) [30 min] Stress-induced localization of Hsp70B’ and Hsp70 to nuclear components of differentiated human neuronal cells R. William Currie (Halifax) [20 min] Sex differences in the induced expression of Hsp70 and Hsp27 in the brain of rats Federico Miozzo (Paris) [20 min] A novel cross-talk between Heat Shock Factors and DNA methylation pathways upon alcohol exposure Daniel Ciocca (Mendoza) [20 min] Response of glioma cells to temozolomide (TMZ) administration, effects on proteins implicated in the protection of their genome integrity Helen Scott (Bristol) [30 min] Investigating the roles mirror-miRNAs play in regulating clathrin-mediated endocytosis and synaptic function |
| 10:30-11:00 |
Morning Tea and Coffee |
| 11:00-13:00 |
Parallel Sessions Metallothioneins Chair: Michael Lynes (Storrs) Michael Lynes (Storrs) [30 min] Within and without: metallothionein influences immune cell functioning on both sides of the plasma membrane Juan Hidalgo (Barcelona) [30 min] Roles of metallothioneins in animal models of neuroinflammation Lindsey Devisscher (Ghent) [30 min] Metallothioneins are danger signals and represent a novel target to dampen inflammation in mice models for colitis David Lawrence (Albany) [30 min] Metallothionein alters the stress associated with Listeriosis and cold restraint Neural Stress Responses II: Mechanisms of Neuroprotection Chairs: Ian Brown (Toronto) & Michael Cheetham (London) Serena Carra (Modena) [30 min] BAG3-mediated re-routing of protein degradation towards autophagy upon proteasomal impairment Nikola Golenhofen (Ulm) [20 min] Overexpression of HspB5/αB-crystallin in cultured hippocampal neurons leads to increased synapse density and dendritic branching David Parfitt (London) [20 min] Pharmacological manipulation of the stress response in retinal degeneration Sergey Onikienko (St Petersburg) [20 min] Recombinant human Hsp70 and their long-acting derivatives serve as potent neuroprotectors in experimental decompression sickness and ischemic stroke animal models Michael Cheetham (London) [30 min] Neuronal stress proteins and neurodegeneration |
|
Congress Closes |
|
| 13:00-14:00 |
Hot Buffet Lunch |
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